LB-100
LB-100 is an inhibitor of protein phosphatase 2A (PP2A) that exhibits pro-angiogenic and anticancer activities. LB-100 increases expression of VEGF and HIF-1α. This compound also decreases growth of pancreatic cancer cells and enhances the activity of other co-administered chemotherapeutics in various cancer models.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1893793
| Cas No. |
1026680-07-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C13H20N2O4 |
| Formula Wt. |
268.31 |
| IUPAC Name |
3-[(4-Methyl-1-piperazinyl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid |
Bai X, Zhi X, Zhang Q, et al. Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis. Cancer Lett. 2014 Dec 28;355(2):281-7. PMID: 25304380.
Bai XL, Zhang Q, Ye LY, et al. Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas. Mol Cancer Ther. 2014 Aug;13(8):2062-72. PMID: 24867249.
