Kassinin
Kassinin is a tachykinin neuropeptide originally found in amphibian skin; it binds neurokinin 2 (NK2) receptors and displays gastrointestinal motility modulating activity. Kassinin stimulates ion transport across skin membranes. Kassinin also induces contractions in bladder muscle and inhibits both gastric acid secretion and gastric emptying.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18936478
| Cas No. |
63968-82-1 |
|---|---|
| Purity |
≥95% |
| Formula |
C59H95N15O18S |
| Formula Wt. |
1334.6 |
| Chemical Name |
L-alpha-Aspartyl-L-valyl-L-prolyl-L-lysyl-L-seryl-L-alpha-aspartyl-L-glutaminyl-L-phenylalanyl-L-valylglycyl-L-leucyl-L-Methioninamide |
| IUPAC Name |
3-amino-4-[[1-[2-[[6-amino-1-[[1-[[1-[[5-amino-1-[[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid |
| Synonym | |
| Appearance |
White to off white powder |
Lippe C, Bellantuono V, Ardizzone C, et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides. 2004 Nov;25(11):1971-5. PMID: 15501529.
Bolle P, Severini C, Falconieri-Erspamer G, et al. Effects of natural tachykinins on porcine lower urinary tract smooth muscle. J Auton Pharmacol. 2000 Jun;20(3):157-61. PMID: 11193004.
Improta G, Broccardo M. Tachykinins: effects on gastric secretion and emptying in rats. Pharmacol Res. 1990 Sep-Oct;22(5):605-10. PMID: 2177557.
