K252a
K252a is an aglycone analog of staurosporine that acts as a protein kinase inhibitor, inhibiting PKC. K252a also inhibits TrkA/B receptors, suppressing activity of neurotrophins such as nerve growth factor (NGF).
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18936143
| Cas No. |
99533-80-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C27H21N3O5 |
| Formula Wt. |
467.48 |
| Synonym |
SF 2370 |
| Melting Point |
262-263°C |
| Solubility |
Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;insoluble in water, 2-propanol |
| Appearance |
White Powder |
El-Hashim AZ, Jaffal SM, Al-Rashidi FT, et al. Nerve growth factor enhances cough via a central mechanism of action. Pharmacol Res. 2013 Aug;74:68-77. PMID: 23742790.
Cardenas-Aguayo Mdel C, Kazim SF, Grundke-Iqbal I, et al. Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures. PLoS One. 2013;8(1):e53596. PMID: 23320097.
Sugiya H, Putney JW Jr. Protein kinase C-dependent and -independent mechanisms regulating the parotid substance P receptor as revealed by differential effects of protein kinase C inhibitors. Biochem J. 1988 Dec 1;256(2):677-80. PMID: 2464997.
Hashimoto S. K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells. J Cell Biol. 1988 Oct;107(4):1531-9. PMID: 2844830.
