JC-1
JC-1 is a potential-dependent J-aggregate-forming cation that is used to detect changes in the mitochondrial membrane potential.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18936064
| Cas No. |
3520-43-2 |
|---|---|
| Purity |
≥90% |
| Formula |
C25H27Cl4IN4 |
| Formula Wt. |
652.23 |
| IUPAC Name |
5,6-Dichloro-2-[(1E)-3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propen-1-yl]-1,3-diethyl-1H-3,1-benzimidazol-3-ium iodide |
| Solubility |
Soluble in methanol, DMSO. |
Zhang C, Tian Y, Song F, et al. Salinomycin inhibits the growth of colorectal carcinoma by targeting tumor stem cells. Oncol Rep. 2015 Sep 8. [Epub ahead of print]. PMID: 26352531.
Jiang Z, Li X, Lin Z, et al. Ethyl pyruvate reduces hepatic mitochondrial swelling and dysfunction in a rat model of sepsis. Int J Clin Exp Pathol. 2015 Jul 1;8(7):7774-85. PMID: 26339342.
Smiley ST, Reers M, Mottola-Hartshorn C, et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3671-5. PMID: 2023917.
