J-147
J-147 is a phenyl hydrazide that exhibits neuroprotective and cognition enhancing activities. In vitro, this compound decreases neuronal loss, oxidative stress, and glutamate-induced neurotoxicity. J-147 also ameliorates memory impairment in animal models of Alzheimer’s disease.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18935962
| Cas No. |
1146963-51-0 |
|---|---|
| Formula |
C18H17F3N2O2 |
| Formula Wt. |
350.34 |
| IUPAC Name |
N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylene]acetohydrazide |
Chen HY, Xu DP, Tan GL, et al. A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine. J Mol Neurosci. 2015 May 17. [Epub ahead of print]. PMID: 25982925.
Prior M, Dargusch R, Ehren JL, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimers disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25. PMID: 23673233.
Chiruta C, Zhao Y, Tang F, et al. Metabolism of a potent neuroprotective hydrazide. Bioorg Med Chem. 2013 May 15;21(10):2733-41. PMID: 23582448.
