Isoniazid
Isoniazid is an antibacterial compound that displays efficacy against Mycobacterium and is clinically used to treat tuberculosis. Isoniazid inhibits InhA, an NADH-dependent enoyl-coA reductase.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18932224
| Cas No. |
54-85-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C6H7N3O |
| Formula Wt. |
137.14 |
| Chemical Name |
4-Pyridinecarboxylic acid, hydrazide |
| IUPAC Name |
pyridine-4-carbohydrazide |
| Synonym |
Isonicotinoylhydrazine; Rimitsid; Tubazid; Cotinazin; Dinacrin; Ditubin; Hycozid. |
| Melting Point |
170-173°C |
| Solubility |
Soluble in water (125 mg/mL, DMSO, methanol and ethanol (20 mg/mL). |
| Appearance |
White Crystal Powder |
Bernardes-Génisson V, Deraeve C, Chollet A, et al. Isoniazid: an update on the multiple mechanisms for a singular action. Curr Med Chem. 2013;20(35):4370-85. PMID: 23931278.
Argyrou A, Vetting MW, Blanchard JS. New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP. J Am Chem Soc. 2007 Aug 8;129(31):9582-3. PMID: 17636923.
Oliveira JS, Vasconcelos IB, Moreira IS, et al. Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents. Curr Drug Targets. 2007 Mar;8(3):399-411. PMID: 17348833.
