INCB-28060
INCB28060 is an inhibitor of c-MET that exhibits anticancer chemotherapeutic activity. In cellular models of cancer, INCB28060 inhibits cell migration and induces apoptosis, inhibiting proliferation. In animal models, this compound inhibits tumor growth.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18931372
| Cas No. |
1029712-80-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C23H17FN6O |
| Formula Wt. |
412.42 |
| IUPAC Name |
2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide |
| Synonym |
INC-280, Capmatinib |
| Appearance |
Yellow Powder |
Liu X, Wang Q, Yang G, et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res. 2011 Nov 15;17(22):7127-38. PMID: 21918175.
