Inauhzin
Inauhzin is an inhibitor of SIRT1 that activates p53; it also inhibits inosine monophosphate dehydrogenase (IMPDH). Inauhzin exhibits anticancer chemotherapeutic activities, inducing apoptosis and suppressing cell growth in non-small cell lung cancer (NSCLC) and colon cancer cells. This compound also induces senescence in and represses tumor growth in cellular and animal models of lung cancer and colon carcinoma.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18931370
| Cas No. |
309271-94-1 |
|---|---|
| Formula |
C25H19N5OS2 |
| Formula Wt. |
469.58 |
| IUPAC Name |
1-(10H-Phenothiazin-10-yl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-1-butanone |
Zhang Q, Zhou X, Wu R, et al. The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress. Elife. 2014 Oct 27;3. PMID: 25347121.
Zhang Y, Zhang Q, Zeng SX, et al. Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents. Neoplasia. 2013 May;15(5):523-34. PMID: 23633924.
