Icariin
Icariin is a flavonol glycoside originally found in Epimedium that exhibits vasodilatory, antidepressant, neuroprotective, antioxidative, and anti-osteoporotic activities. Icariin inhibits phosphodiesterase 5 (PDE5), increasing cGMP and NO concentrations. Icariin inhibits AAPH-induced oxidative DNA damage in vitro. In animal models, icariin decreases immobility time in the forced swim and tail suspension tests and decreases stress-induced expression of monoamine oxidases (MAOs). In other animals, icariin improves searching time and distance in the Morris water maze; it also decreases levels of malondialdehyde and amyloid-β (Aβ) in animal models of Alzheimer’s disease. This compound also inhibits osteoclast growth and differentiation, potentially suppressing bone resorption.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18931336
| Cas No. |
489-32-7 |
|---|---|
| Purity |
≥97% |
| Formula |
C33H40O15 |
| Formula Wt. |
676.66 |
| Chemical Name |
3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-7-(β-D- glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one |
| IUPAC Name |
5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one |
| Melting Point |
231.5°C |
| Solubility |
Soluble in pyridine. Insoluble in water, alcohol, chloroform, acetone, methanol or ethyl acetate. |
| Appearance |
Fine Yellow Powder |
Zhao F, Tang YZ, Liu ZQ. Protective effect of icariin on DNA against radical-induced oxidative damage. J Pharm Pharmacol. 2007 Dec;59(12):1729-32. PMID: 18053336.
Luo Y, Nie J, Gong QH, et al. Protective effects of icariin against learning and memory deficits induced by aluminium in rats. Clin Exp Pharmacol Physiol. 2007 Aug;34(8):792-5. PMID: 17600559.
Chen KM, Ge BF, Liu XY, et al. Icariin inhibits the osteoclast formation induced by RANKL and macrophage-colony stimulating factor in mouse bone marrow culture. Pharmazie. 2007 May;62(5):388-91. PMID: 17557750.
Ning H, Xin ZC, Lin G, et al. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology. 2006 Dec;68(6):1350-4. PMID: 17169663.
Pan Y, Kong L, Xia X, et al. Antidepressant-like effect of icariin and its possible mechanism in mice. Pharmacol Biochem Behav. 2005 Dec;82(4):686-94. PMID: 16380159.
