HPGDS-inhibitor-1
HPGDS Inhibitor 1 is an inhibitor of hematopoietic prostaglandin D synthase (HPGDS) that decreases release of PGD2. HPGDS Inhibitor 1 displays anti-inflammatory, anti-allergic, and immunomodulatory activities, decreasing antigen-induced immune and inflammation responses in animal models.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18931141
| Cas No. |
1033836-12-2 |
|---|---|
| Formula |
C19H19F4N3O |
| Formula Wt. |
381.37 |
| IUPAC Name |
6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]nicotinamide |
| Synonym |
Prostaglandin D Synthase (hematopoietic-type) Inhibitor I |
Carron CP, Trujillo JI, Olson KL, et al. Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS). ACS Med Chem Lett. 2010 Feb 2;1(2):59-63. PMID: 24900177.
