Guaifenesin
Guaifenesin is an expectorant that alleviates symptoms of mucus accumulation. Guaifenesin inhibits mucin production, increases mucociliary transport, and decreases the viscoelasticity of mucus in airway epithelial cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18929698
| Cas No. |
93-14-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C10H14O4 |
| Formula Wt. |
198.22 |
| Chemical Name |
3-(2-Methoxyphenoxy)-1,2-propanediol |
| IUPAC Name |
3-(2-methoxyphenoxy)propane-1,2-diol |
| Synonym |
Glycerol guaiacolate; Equicol; Glycodex; Miocaina; Oresol; Relaxil G; Sirotol; Tulyn |
| Melting Point |
78.5-79°C |
| Solubility |
Soluble in water (14 mg/mL), ethanol, chloroform, DMF, or glycerol. |
Seagrave J, Albrecht H, Park YS, et al. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp Lung Res. 2011 Dec;37(10):606-14. PMID: 22044398.
Kagan L, Lavy E, Hoffman A. Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model. Pulm Pharmacol Ther. 2009 Jun;22(3):260-5. PMID: 19166957.
