GSK-2830371
GSK-2830371 is an inhibitor of wild-type p53-induced phosphatase 1 (Wip1) that exhibits anticancer chemotherapeutic activity. In animal models of lymphoma, GSK-2830371 inhibits cell growth and tumor growth. In neuroblastoma cells, this compound induces cell death.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18929505
| Cas No. |
1404456-53-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C23H29ClN4O2S |
| Formula Wt. |
461.02 |
| IUPAC Name |
5-{[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl}-N-[(2S)-3-cyclopentyl-1-(cyclopropylamino)-1-oxo-2-propanyl]-2-thiophenecarboxamide |
| Appearance |
Yellow to off white powder |
Richter M, Dayaram T, Gilmartin AG, et al. WIP1 Phosphatase as a Potential Therapeutic Target in Neuroblastoma. PLoS One. 2015 Feb 6;10(2):e0115635. PMID: 25658463.
Gilmartin AG, Faitg TH, Richter M, et al. Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. Nat Chem Biol. 2014 Mar;10(3):181-7. PMID: 24390428.
