GSK-2334470
GSK-2334470 is a selective inhibitor of PI3K that exhibits anticancer activity in in vitro models. GSK-2334470 inhibits T-loop phosphorylation of PI3K substrates SGK and S6K1, Akt and Akt substrates GSK3, FoxO, and PRAS40, and ERK substrate RSK2. This compound also inhibits PDK1.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18929395
| Cas No. |
1227911-45-6 |
|---|---|
| Purity |
≥99%, ≥99%ee |
| Formula |
C25H34N8O |
| Formula Wt. |
462.59 |
| IUPAC Name |
(3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide |
| Solubility |
Soluble in DMSO |
| Appearance |
off-white powder |
Najafov A, Sommer EM, Axten JM, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J. 2011 Jan 15;433(2):357-69. PMID: 21087210.
