GNE-7915
GNE-7915 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2). GNE-7915 exhibits neuroprotective activity and is in development as a potential treatment for neurodegenerative disorders such as Parkinson’s disease.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18928825
| Cas No. |
1351761-44-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C19H21F4N5O3 |
| Formula Wt. |
443.40 |
| IUPAC Name |
(4-{[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino}-2-fluoro-5-methoxyphenyl)(4-morpholinyl)methanone |
| Synonym |
GNE7915 |
| Appearance |
White Crystal Powder |
Kavanagh ME, Doddareddy MR, Kassiou M. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6. PMID: 23721803.
Estrada AA, Liu X, Baker-Glenn C, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33. PMID: 22985112.
