Furosemide
Furosemide is a loop diuretic that is clinically used to treat congestive heart failure, edema, and hypertension; it inhibits the Na+/K+/Cl2- (NKCC) symporter and CFTR Cl- channels in the loop of Henle, decreasing reabsorption of Na+ and K+ and increasing secretion of Mg2+ and Ca2+. Furosemide exhibits antihypertensive, anxiolytic, and potentially antiepileptic/anticonvulsant activities. Furosemide noncompetitively inhibits GABA-A receptors and decreases conditioned anxiety in animal models of contextual fear conditioning and fear-potentiated startle.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18925914
| Cas No. |
54-31-9 |
|---|---|
| Purity |
≥97% |
| Formula |
C12H11ClN2O5S |
| Formula Wt. |
330.74 |
| Chemical Name |
5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)- amino]benzoic acid |
| IUPAC Name |
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid |
| Synonym |
Fursemide; Beronald; Discoid; Durafurid; Eutensin; Fulsix; Furosedon; Impugan; Katlex; Lasix; Macasirrol; Nicorol; Odemase; Rosemide; Urex |
| Melting Point |
203-206°C |
| Solubility |
Soluble in acetone, DMF, and methanol. Slightly soluble in water, chloroform and ether. |
| Appearance |
Cream/ Off-White powder |
Ju M, Scott-Ward TS, Liu J, et al. Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics. Br J Pharmacol. 2014 Jan;171(1):265-78. PMID: 24117047.
Krystal AD, Sutherland J, Hochman DW. Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. PLoS One. 2012;7(4):e35417. PMID: 22514741.
Somasekharan S, Tanis J, Forbush B. Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1). J Biol Chem. 2012 May 18;287(21):17308-17. PMID: 22437837.
Korpi ER, Kuner T, Seeburg PH, et al. Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1995 Feb;47(2):283-9. PMID: 7870036.
