Formestane
Formestane is a steroidal androgen substrate that inhibits aromatase. Formestane is clinically used to treat ER+ breast cancer, as it inhibits production of estrogens.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18925636
| Cas No. |
566-48-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C19H26O3 |
| Formula Wt. |
302.41 |
| Chemical Name |
4-Hydroxyandrost-4-ene-3,17-dione |
| IUPAC Name |
(8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione |
| Synonym |
4-OHA; Lentaron |
| Melting Point |
199-202°C |
| Solubility |
Soluble in methanol. |
| Appearance |
White Crystalline Powder |
Miller WR. Aromatase inhibitors: mechanism of action and role in the treatment of breast cancer. Semin Oncol. 2003 Aug;30(4 Suppl 14):3-11. PMID: 14513432.
Dowsett M. Aromatase inhibition: basic concepts, and the pharmacodynamics of formestane. Ann Oncol. 1994;5 Suppl 7:S3-5. PMID: 7873460.
