Flurbiprofen
Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) that is clinically used to treat arthritis. Flurbiprofen is a non-selective inhibitor of COX-1 and COX-2 that exhibits analgesic, anti-inflammatory, neuroprotective, anti-metastatic, and anticancer chemotherapeutic activities. In vivo, flurbiprofen suppresses injury induced by cerebral ischemia/reperfusion, decreasing infarct volume, apoptosis, and neurological deficits. In cellular and animal models of gastric cancer, flurbiprofen downregulates expression of cyclin D1 and CDK4, upregulates expression of p75, and decreases cellular proliferation, metastasis, and tumor size.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18925334
| Cas No. |
5104-49-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C15H13FO2 |
| Formula Wt. |
244.26 |
| Chemical Name |
2-Fluoro-α-methyl[1,1-biphenyl]-4-acetic acid |
| IUPAC Name |
2-(3-fluoro-4-phenylphenyl)propanoic acid |
| Synonym |
Adfeed; Ansaid; Antadys; Cebutid; Froben; Flurofen |
| Melting Point |
110-111°C |
| Solubility |
Slightly soluble in water (8mg/mL). |
| Appearance |
White Crystal Powder |
Sun B, Chen L, Wei X, et al. The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. Biochem Biophys Res Commun. 2011 Jun 17;409(4):808-13. PMID: 21624354.
Jin H, Wang Z, Liu L, et al. R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction. Mol Pharm. 2010 Feb 1;7(1):156-68. PMID: 19916560.
