Fenbufen
Fenbufen is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2; it exhibits anti-inflammatory, analgesic, and antioxidative activities. Fenbufen is clinically used to treat rheumatoid arthritis, tendinitis, and ankylosing spondylitis. In vitro, fenbufen scavenges O2 radicals and ROS.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18922932
| Cas No. |
36330-85-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H14O3 |
| Formula Wt. |
254.28 |
| Chemical Name |
γ-Oxo-[1,1-biphenyl]-4-butanoic acid |
| IUPAC Name |
4-oxo-4-(4-phenylphenyl)butanoic acid |
| Synonym |
Bufemid; Cinopol; Lederfen |
| Melting Point |
185-187°C |
| Solubility |
Soluble in dimethyl sulfoxide. |
| Appearance |
White or Almost White Crystalline Powder |
Moore RA, Derry S, McQuay HJ. Single dose oral fenbufen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007547. PMID: 19821427.
Costa D, Moutinho L, Lima JL, et al. Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs. Biol Pharm Bull. 2006 Aug;29(8):1659-70. PMID: 16880623.
