Fenbendazole
Fenbendazole is a benzimidazole anti-parasitic/anti-helminthic that is used in veterinary medicine to treat infections of Giardia, Strongyloides, and various worms. Fenbendazole binds fungal tubulin, preventing microtubule polymerization and inhibiting hyphal growth and nuclear division.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18922931
| Cas No. |
43210-67-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C15H13N3O2S |
| Formula Wt. |
299.35 |
| Chemical Name |
[5-(Phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester |
| IUPAC Name |
methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate |
| Synonym |
HOE-881v; Panacur; SafeGard |
| Melting Point |
233°C (dec) |
| Solubility |
Insoluble in water. Slightly soluble in most organic solvents. Soluble in DMSO. |
| Appearance |
A white or almost white crystalline powder |
Küster T, Stadelmann B, Aeschbacher D, et al. Activities of fenbendazole in comparison with albendazole against Echinococcus multilocularis metacestodes in vitro and in a murine infection model. Int J Antimicrob Agents. 2014 Apr;43(4):335-42. PMID: 24646943.
Lubega GW, Prichard RK. Specific interaction of benzimidazole anthelmintics with tubulin: high-affinity binding and benzimidazole resistance in Haemonchus contortus. Mol Biochem Parasitol. 1990 Jan 15;38(2):221-32. PMID: 2325707.
Prichard RK. Anthelmintics for cattle. Vet Clin North Am Food Anim Pract. 1986 Jul;2(2):489-501. PMID: 3488116.
