Estrone
Estrone is an endogenous estrogenic steroid hormone that is secreted mainly in the ovary and in adipose tissue. Estrone exhibits carcinogenic potential, forming DNA adducts in vitro.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18922620
| Cas No. |
53-16-7 |
|---|---|
| Purity |
≥97% |
| Formula |
C18H22O2 |
| Formula Wt. |
270.37 |
| Chemical Name |
3-Hydroxyestra-1,3,5(10)-tri-en-17-onne |
| IUPAC Name |
(8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one |
| Synonym |
Oestrone; Flliculinn; Tokokin; Hiestrone; Glandubolin; Kolponn; Homrovarine; Wynestron; Kestron; Follestrine |
| Melting Point |
254.5-256°C |
| Solubility |
Insoluble in water, Sparingly soluble in ethanol (4 mg/mL). Soluble in acetone (20 mg/mL at 50 oC), chloroform, benzene, dioxane, pyridine or fixed alkali hydroxide solutions. |
| Appearance |
White Crystal Powder |
Rizzati V, Rathahao E, Gamet-Payrastre L, et al. In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. PMID: 15763594.
Borges C, Lemière F, Embrechts J, et al. Characterisation of estrone-nucleic acid adducts formed by reaction of 3,4-estrone-o-quinone with 2-deoxynucleosides/deoxynucleotides using capillary liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2004;18(19):2191-200. PMID: 15384136.
