Epoxiconazole
Epoxiconazole is a triazole pesticide/fungicide with broad antifungal activity. Like many azole fungicides, epoxiconazole likely inhibits 14-α demethylase, inhibiting ergosterol production and fungal cell wall synthesis. Additionally, epoxiconazole may inhibit aromatase and act as an endocrine disrupter. Epoxiconazole displays varying effects on development in vivo, depending on the species utilized.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1891977
| Cas No. |
106325-08-0 |
|---|---|
| Purity |
≥95% |
| Formula |
C17H13ClFN3O |
| Formula Wt. |
329.76 |
| IUPAC Name |
1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole |
| Melting Point |
125 |
| Appearance |
White to off white powder |
Schneider S, Hofmann T, Stinchcombe S, et al. Species differences in developmental toxicity of epoxiconazole and its relevance to humans. Birth Defects Res B Dev Reprod Toxicol. 2013 Jun;98(3):230-46. PMID: 23630118.
Kjærstad MB, Taxvig C, Nellemann C, et al. Endocrine disrupting effects in vitro of conazole antifungals used as pesticides and pharmaceuticals. Reprod Toxicol. 2010 Dec;30(4):573-82. PMID: 20708073.
Taxvig C, Vinggaard AM, Hass U, et al. Endocrine-disrupting properties in vivo of widely used azole fungicides. Int J Androl. 2008 Apr;31(2):170-7. PMID: 18067565.
Taxvig C, Hass U, Axelstad M, et al. Endocrine-disrupting activities in vivo of the fungicides tebuconazole and epoxiconazole. Toxicol Sci. 2007 Dec;100(2):464-73. PMID: 17785682.
