Dihydrosanguinarine
Dihydrosanguinarine (DHS) is a benzophenanthridine alkaloid that is a metabolite of sanguinarine. This compound exhibits a wide variety of antimicrobial activities (anti-parasitic, antifungal, and antibacterial) as well as anticancer and anti-inflammatory properties. DHS is active against Leishmania, Botrytis, Erysiphe, Candida, and various gram positive and gram negative bacteria including MRSA. In leukemia cells, DHS induces dissipation of the mitochondrial membrane potential, resulting in apoptosis and necrosis. DHS also binds DNA sequences containing alternating G and C base pairs. In vitro, DHS also inhibits LPS-induced production of NO and IL-6 and inhibits phosphorylation of ERK1/2 and p38.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18872858
| Cas No. |
3606-45-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H15NO4 |
| Formula Wt. |
333.34 |
| Appearance |
White to off white powder |
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Yao JY, Zhou ZM, Li XL, et al. Antiparasitic efficacy of dihydrosanguinarine and dihydrochelerythrine from Macleaya microcarpa against Ichthyophthirius multifiliis in richadsin (Squaliobarbus curriculus). Vet Parasitol. 2011 Dec 29;183(1-2):8-13. PMID: 21813242.
Feng G, Zhang J, Liu YQ. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9. PMID: 21500094.
Choi JG, Kang OH, Chae HS, et al. Antibacterial activity of Hylomecon hylomeconoides against methicillin-resistant Staphylococcus aureus. Appl Biochem Biotechnol. 2010 Apr;160(8):2467-74. PMID: 19578993.
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Bai LP, Zhao ZZ, Cai Z, et al. DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine. Bioorg Med Chem. 2006 Aug 15;14(16):5439-45. PMID: 16730995.
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