Diflunisal
Diflunisal is a long-acting non-steroidal anti-inflammatory drug (NSAID) that is clinically used to treat arthritis and dental pain. Diflunisal inhibits COX-1 and COX-2, exhibiting anti-inflammatory, antipyretic, analgesic, and antiviral activities. In vitro, diflunisal inhibits docking of HIV-1 to LEDGF/p75, preventing viral integration.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1886650
| Cas No. |
22494-42-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C13H8F2O3 |
| Formula Wt. |
250.20 |
| Chemical Name |
2,4-Difluoro-4-hydroxy-[1,1-biphenyl]-3-carboxylic acid |
| IUPAC Name |
5-(2,4-difluorophenyl)-2-hydroxybenzoic acid |
| Synonym |
Adomal; Difludol; Dolisal; Dolobid; Dolobis; Flovacil; Fluniget; Fluodonil |
| Melting Point |
210-211°C |
| Solubility |
Sparingly soluble in water. |
| Appearance |
White Crystalline Powder or Colorless Crystals |
Hu G, Li X, Sun X, et al. Identification of old drugs as potential inhibitors of HIV-1 integrase – human LEDGF/p75 interaction via molecular docking. J Mol Model. 2012 Dec;18(12):4995-5003. PMID: 22733274.
Lawton GM, Chapman PJ. Diflunisal–a long-acting non-steroidal anti-inflammatory drug. A review of its pharmacology and effectiveness in management of postoperative dental pain. Aust Dent J. 1993 Aug;38(4):265-71. PMID: 8216032.
