Diclazuril
Diclazuril is an anti-parasitic compound that is commercially used in poultry and livestock feed. Diclazuril acts as a coccidiostat. In vivo, diclazuril protects against Toxoplasma infection and induces apoptosis in Eimeria by inhibiting activity of GAPDH.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18865105
| Cas No. |
101831-37-2 |
|---|---|
| Purity |
≥98% |
| Formula |
C17H10Cl2N4O2 |
| Formula Wt. |
407.64 |
| Chemical Name |
2,6-Dichloro-a-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile |
| IUPAC Name |
2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile |
| Synonym |
R-64433; Clinacox |
| Melting Point |
290.5°C |
| Solubility |
Insoluble in water. |
| Appearance |
Off-White Crystal Powder |
Oz HS, Tobin T. Diclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis. Int J Clin Med. 2014 Jan 1;5(3):93-101. PMID: 24851194.
Wang C, Han C, Li T, et al. Nuclear translocation and accumulation of glyceraldehyde-3-phosphate dehydrogenase involved in diclazuril-induced apoptosis in Eimeria tenella (E. tenella). Vet Res. 2013 May 7;44:29. PMID: 23651214.
