Desmopressin
Desmopressin is a synthetic peptide derivative of arginine vasopressin that binds and activates vasopressin-2 receptors (V2Rs). Desmopressin exhibits pro-coagulant/pro-thrombotic and antidiuretic activities and is clinically used to treat bleeding disorders such as hemophilia. Desmopressin enhances platelet pro-coagulant activity and increase platelet-dependent thrombin generation in a Na+/Ca2+-dependent manner.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1885777
| Cas No. |
16679-58-6 |
|---|---|
| Purity |
≥95% |
| Formula |
C46H64N14O12S2 |
| Formula Wt. |
1069.1 |
| Chemical Name |
1-(3-mercaptopropanoic acid)-8-D-arginine vasopressin |
| IUPAC Name |
N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide |
| Synonym |
Minirin; Desmospray; Adiuretin SD. |
| Appearance |
White to off-white powder |
Colucci G, Stutz M, Rochat S, et al. The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT-platelets in patients with primary platelet function defects. Blood. 2014 Jan 17. [Epub ahead of print]. PMID: 24443440.
Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.
Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.
Slusarz MJ, Slusarz R, Ciarkowski J. Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006 Apr 5;81(5):321-38. PMID: 16333859.
