D-Cycloserine
D-Cycloserine is an antibiotic compound that exhibits antibacterial activity against Mycobacterium tuberculosis; it inhibits D-Ala-D-Ala ligase. Additionally, D-cycloserine acts as a glycine site partial agonist at NMDA receptors, enhancing memory and learning and potentially displaying antidepressant and cognition enhancing activities.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18855153
| Cas No. |
68-41-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C3H6N2O2 |
| Formula Wt. |
102.09 |
| Chemical Name |
D-4-Amino-3-isoxazolidinone |
| IUPAC Name |
(4R)-4-amino-1,2-oxazolidin-3-one |
| Synonym |
Closina; Farmiserina; Micoserina; Oxamycin; Seromycin. |
| Melting Point |
155-156°C |
| Solubility |
Soluble in water. Slightly soluble in methanol or propylene glycol. |
| Appearance |
White powder (may gradually turn blue over time) |
Dang YH, Ma XC, Zhang JC, et al. Targeting of NMDA Receptors in the Treatment of Major Depression. Curr Pharm Des. 2014 Jan 10. [Epub ahead of print]. PMID: 24410564.
Prosser GA, de Carvalho LP. Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis. ACS Med Chem Lett. 2013 Dec 12;4(12):1233-1237. PMID: 24478820.
Portero-Tresserra M, Martí-Nicolovius M, Guillazo-Blanch G, et al. D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats. Neurobiol Learn Mem. 2013 Feb;100:1-11. PMID: 23200640.
