CZC-54252
CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2) that exhibits neuroprotective activity. This compound may decrease neuronal injury in models of neurodegenerative diseases such as Parkinson’s disease.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18855093
| Cas No. |
1191911-27-9 |
|---|---|
| Formula |
C22H25ClN6O4S |
| Formula Wt. |
504.99 |
| IUPAC Name |
N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide |
Kramer T, Lo Monte F, Göring S, et al. Small molecule kinase inhibitors for LRRK2 and their application to Parkinsons disease models. ACS Chem Neurosci. 2012 Mar 21;3(3):151-60. PMID: 22860184.
Ramsden N, Perrin J, Ren Z, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinsons disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. PMID: 21812418.
