Cylindrospermopsin
Cylindrospermopsin is a cyanotoxin that was initially produced by the cyanobacterium Cylindrospermopsis raciborskii. Cylindrospermopsin inhibits protein and glutathione synthesis in vitro, inducing oxidative stress, double-stranded DNA breaks, and cell cycle arrest. In vivo, cylindrospermopsin induces degeneration and steatosis in the liver, glomerulopathy in the kidney, and myofibrolysis and edema in the heart. Cylindrospermopsin may be considered carcinogenic.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18854727
| Cas No. |
143545-90-8 |
|---|---|
| Purity |
≥95% |
| Formula |
C15H21N5O7S |
| Formula Wt. |
415.42 |
| Solubility |
Soluble in Methanol and DMSO |
| Appearance |
Clear film |
Gutiérrez-Praena D, Risalde MA, Pichardo S, et al. Histopathological and immunohistochemical analysis of Tilapia (Oreochromis niloticus) exposed to cylindrospermopsin and the effectiveness of N-Acetylcysteine to prevent its toxic effects. Toxicon. 2013 Nov 28;78C:18-34. [Epub ahead of print]. PMID: 24291634.
Guzmán-Guillén R, Prieto AI, Moreno I, et al. Cyanobacterium producing cylindrospermopsin cause histopathological changes at environmentally relevant concentrations in subchronically exposed tilapia (Oreochromis niloticus). Environ Toxicol. 2013 Sep 2. [Epub ahead of print]. PMID: 24000190.
Alja Š, Filipič M, Novak M, et al. Double strand breaks and cell-cycle arrest induced by the cyanobacterial toxin cylindrospermopsin in HepG2 cells. Mar Drugs. 2013 Aug 21;11(8):3077-90. PMID: 23966038.
López-Alonso H, Rubiolo JA, Vega F, et al. Protein synthesis inhibition and oxidative stress induced by cylindrospermopsin elicit apoptosis in primary rat hepatocytes. Chem Res Toxicol. 2013 Feb 18;26(2):203-12. PMID: 23270326.
