Coumarin
Coumarin is a benzopyrone found in many plants such as the Tonka bean and sweet woodruff. Coumarin is commonly used in perfumes and fabric conditioners for its sweet odor. Coumarin is a precursor in the synthesis of anticoagulants such as warfarin; coumarin inhibits vitamin K. Coumarin is clinically used to treat edema, as it stimulates macrophages to degrade extracellular albumen, allowing increased fluid reabsorption. Coumarin is also used in dyes and bio-imaging. Derivatives of coumarin exhibit immunomodulatory, anticancer, and antimicrobial activities.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18853679
| Cas No. |
91-64-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C9H6O2 |
| Formula Wt. |
146.14 |
| Chemical Name |
2H-1-Benzopyran-2-one |
| IUPAC Name |
chromen-2-one |
| Synonym |
Cumarin; Coumarinic anhydride; Tonka bean camphor |
| Melting Point |
68-70°C |
| Solubility |
Slightly soluble in water. Soluble in alcohol, chloroform, ether, alkali hydroxide solutions or oils. |
| Appearance |
Large, Semi-Clear Crystals |
Kontogiorgis C, Detsi A, Hadjipavlou-Litina D. Coumarin-based drugs: a patent review (2008 — present). Expert Opin Ther Pat. 2012 Apr;22(4):437-54. PMID: 22475457.
Farinola N, Piller N. Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema. Lymphat Res Biol. 2005 Summer;3(2):81-6. PMID: 16000056.
