Corydaline
Corydaline is an alkaloid compound originally found in Corydalis tubers. Corydaline exhibits gastrointestinal modulatory, antinociceptive, anti-allergic, and anti-parasitic activities. Corydaline is currently in clinical trials as a potential treatment for functional dyspepsia. In animal models, corydaline increases gastric emptying and small intestine transit speed and induces gastric relaxation. In other animal models, corydaline inhibits chemically-induced pain. Additionally, this compound may inhibit mast cell-dependent smooth muscle contraction of the aorta. Corydaline also exhibits nematocidal activity against species of Strongyloides.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18853475
| Cas No. |
518-69-4 |
|---|---|
| Purity |
≥95% |
| Formula |
C22H27NO4 |
| Formula Wt. |
369.45 |
| IUPAC Name |
(13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline |
| Appearance |
White to off white powder |
Lee TH, Son M, Kim SY. Effects of corydaline from Corydalis tuber on gastric motor function in an animal model. Biol Pharm Bull. 2010;33(6):958-62. PMID: 20522959.
Wang C, Wang S, Fan G, et al. Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry. Anal Bioanal Chem. 2010 Mar;396(5):1731-40. PMID: 20101504.
Saito SY, Tanaka M, Matsunaga K, et al. The combination of rat mast cell and rabbit aortic smooth muscle is the simple bioassay for the screening of anti-allergic ingredient from methanolic extract of Corydalis tuber. Biol Pharm Bull. 2004 Aug;27(8):1270-4. PMID: 15305035.
Satou T, Koga M, Matsuhashi R, et al. Assay of nematocidal activity of isoquinoline alkaloids using third-stage larvae of Strongyloides ratti and S. venezuelensis. Vet Parasitol. 2002 Mar 1;104(2):131-8. PMID: 1180933.
