Corticosterone
Corticosterone is an endogenous steroid hormone that activates mineralocorticoid and glucocorticoid receptors. Corticosterone is involved in immune responses, stress responses, and energy homeostasis. Corticosterone is an intermediate in the aldosterone production pathway.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18853399
| Cas No. |
50-22-6 |
|---|---|
| Purity |
≥96% |
| Formula |
C21H30O4 |
| Formula Wt. |
346.46 |
| Chemical Name |
(11-β)-11,21-Dihydroxypregn-4-ene-3,20-dione |
| IUPAC Name |
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| Synonym |
Kendalls compound B; Reichsteins substance H; Compound B |
| Melting Point |
180-182°C |
| Solubility |
Insoluble in water. Soluble in organic solvents. |
| Appearance |
Off-white powder |
Angelier F, Wingfield JC. Importance of the glucocorticoid stress response in a changing world: theory, hypotheses and perspectives. Gen Comp Endocrinol. 2013 Sep 1;190:118-28. PMID: 23770214.
Silverman MN, Sternberg EM. Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci. 2012 Jul;1261:55-63. PMID: 22823394.
Williams GH. Aldosterone biosynthesis, regulation, and classical mechanism of action. Heart Fail Rev. 2005 Jan;10(1):7-13. PMID: 15947886.
