Clofibrate
Clofibrate is a fibrate compound that exhibits anti-hyperlipidemic and anticancer activities. Clofibrate acts as an agonist at PPARα, increasing lipoprotein lipase and HDL and decreasing triglycerides and VLDL. In leukemia cells, clofibrate induces G0/G1 phase cell cycle arrest and differentiation, decreases levels of c-myb and cyclin D2, and inhibits cellular growth.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18852441
| Cas No. |
637-07-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C12H15ClO3 |
| Formula Wt. |
242.70 |
| Chemical Name |
2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester |
| IUPAC Name |
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate |
| Synonym |
Amotril; Apolan; Ateriosan; Claripex; CPIB; Liprinal; Normet; Recolip; Xyduril |
| Melting Point |
<25°C |
| Solubility |
Soluble in DMSO or ethanol. Insoluble in water. |
| Appearance |
Golden-Yellow Liquid |
Laurora S, Pizzimenti S, Briatore F, et al. Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. PMID: 12649303.
Nicholls-Grzemski FA, Calder IC, Priestly BG, et al. Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis. Toxicol Sci. 2000 Jul;56(1):220-8. PMID: 10869471.
