Cabozantinib
Cabozantanib is an anticancer chemotherapeutic compound that has been approved to treat medullary thyroid cancer and is in clinical trials as a treatment for other types of solid tumors. Cabozantanib exerts its anticancer activity through inhibition of Met, RET, and VEGFR2, increasing apoptosis and inhibiting cell growth and osteoclast proliferation in vitro and in vivo.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18846087
| Cas No. |
849217-68-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C28H24FN3O5 |
| Formula Wt. |
501.51 |
| Chemical Name |
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
| IUPAC Name |
1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
| Synonym |
XL-184, BMS-907351 |
| Solubility |
Soluble in DMSO (≥117mg/mL), insoluble in water (≤1 mg/mL). |
| Appearance |
White to off white powder |
Dai J, Zhang H, Karatsinides A, et al. Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions. Clin Cancer Res. 2013 Oct 4. [Epub ahead of print]. PMID: 24097861.
Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol. 2013 Oct 10;31(29):3639-46. PMID: 24002501.
Bentzien F, Zuzow M, Heald N, et al. In Vitro and In Vivo Activity of Cabozantinib (XL184), an Inhibitor of RET, MET, and VEGFR2, in a Model of Medullary Thyroid Cancer. Thyroid. 2013 Sep 17. [Epub ahead of print]. PMID: 23705946.
Navis AC, Bourgonje A, Wesseling P, et al. Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2. PLoS One. 2013;8(3):e58262. PMID: 23484006.
