BX-795
BX-795 inhibits PDK1, exhibiting anticancer chemotherapeutic activity. BX-795 inhibits Akt signaling, inducing apoptosis and suppressing tumor growth.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18845643
| Cas No. |
702675-74-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C23H26IN7O2S |
| Formula Wt. |
591.47 |
| IUPAC Name |
N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide |
| Synonym |
BX795 |
| Appearance |
White to off white powder |
Feldman RI, Wu JM, Polokoff MA, et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. PMID: 15772071.
