BMS-599626
BMS-599626 is a pan-HER inhibitor (including EGFR and VEGFR) that is currently in clinical trials as a potential treatment against several forms of cancer. BMS-599626 displays anticancer chemotherapeutic activity. In head and neck squamous cell carcinoma cells, BMS-599626 induces G1 phase cell cycle arrest and inhibits cell growth; in vivo, it improves responses to radiation.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18844844
| Cas No. |
714971-09-2 |
|---|---|
| Purity |
≥98% |
| Formula |
C27H27FN8O3 |
| Formula Wt. |
530.55 |
| Synonym |
BMS599626, AC480 |
| Appearance |
White to off white powder |
Soria JC, Cortes J, Massard C, et al. Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors. Ann Oncol. 2012 Feb;23(2):463-71. PMID: 21576284.
Torres MA, Raju U, Molkentine D, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29(4):554-61. PMID: 20119866.
