BI-2536
BI-2536 is a polo-like kinase 1 (PLK1) inhibitor that disrupts mitosis and cell division. BI-2536 exhibits anticancer activity and may induce apoptosis in cancer cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18843938
| Cas No. |
755038-02-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C28H39N7O3 |
| Formula Wt. |
521.65 |
| Synonym |
BI2536 |
| Appearance |
Pale yellow to off-white powder |
Colnaghi R, Wheatley SP. Liaisons between survivin and Plk1 during cell division and cell death. J Biol Chem. 2010 Jul 16;285(29):22592-604. PMID: 20427271.
Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nature Reviews Cancer. 2009 Jan;9:28-39.
