Artemisinin
Artemisinin is a sesquiterpene lactone originally found in Artemisia (wormwood); it is clinically used to treat malaria. Artemisinin exhibits anti-parasitic, antimalarial, cardioprotective, anticancer, and anti-inflammatory activities. This compound inhibits growth of Plasmodium. In animal models of myocardial infarction, artemisinin decreases ventricular fibrillation threshold and levels of TNF-α and increases expression of connexin 43. In macrophages, this compound inhibits IL-6 release. Artemisinin also inhibits growth of neuroblastoma cells, increasing activation of AMPK and decreasing signaling by mTOR.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18842629
| Cas No. |
63968-64-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C15H22O5 |
| Formula Wt. |
282.35 |
| Chemical Name |
(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-tri- methyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzo- dioxepin-10(3H)-one |
| Synonym |
Artemisine; Arteannuin; Quinghaosu; QHS |
| Melting Point |
156-157°C |
| Solubility |
Insoluble in water. Soluble in DMSO, acetone, ethanol, or chloroform |
| Appearance |
White crystalline solid |
Gu Y, Wu G, Wang X, et al. Artemisinin prevents electric remodeling following myocardial infarction possibly by upregulating the expression of connexin 43. Mol Med Rep. 2014 Oct;10(4):1851-6. PMID: 25110145.
Tan WQ, Chen G, Jia B, et al. Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling. Pharmazie. 2014 Jun;69(6):468-72. PMID: 24974584.
Patel K, Batty KT, Moore BR, et al. Predicting the parasite killing effect of artemisinin combination therapy in a murine malaria model. J Antimicrob Chemother. 2014 Aug;69(8):2155-63. PMID: 24777899.
Yu WY, Kan WJ, Yu PX, et al. Anti-inflammatory effect and mechanism of artemisinin and dihydroartemisinin. Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2618-21. PMID: 23236763.
