Amoxicillin
Amoxicillin is a β-lactam penicillin antibiotic that exhibits antibacterial efficacy against both gram positive and gram negative bacteria. Amoxicillin inhibits peptidoglycan polymerization through binding of penicillin binding proteins, inhibiting cell wall synthesis.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18838381
| Cas No. |
26787-78-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H19N3O5S |
| Formula Wt. |
365.41 |
| Chemical Name |
(2S,5R,6R)-6-[[(2R)-amino(4-hydroxyphenyl)- acetyl]amino]-3,3-dimethyl-7-oxo-4-Thia-1-azabicyclo-[3.2.0]heptane-2-carboxylic acid |
| IUPAC Name |
(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Synonym |
Amoxycillin; Amolin; Amopenixin; Helvamox; Moxal; Pasetocin; AMPC |
| Melting Point |
194°C |
| Solubility |
Soluble in water, DMSO, ethanol. |
| Appearance |
White to off white powder |
Astasov-Frauenhoffer M, Braissant O, Hauser-Gerspach I, et al. Microcalorimetric determination of the effects of amoxicillin, metronidazole, and their combination on in vitro biofilm. J Periodontol. 2014 Feb;85(2):349-57. PMID: 23594193.
Martin SI, Kaye KM. Beta-lactam antibiotics: newer formulations and newer agents. Infect Dis Clin North Am. 2004 Sep;18(3):603-19. PMID: 15308278.
Weber DJ, Tolkoff-Rubin NE, Rubin RH. Amoxicillin and potassium clavulanate: an antibiotic combination. Mechanism of action, pharmacokinetics, antimicrobial spectrum, clinical efficacy and adverse effects. Pharmacotherapy. 1984 May-Jun;4(3):122-36. PMID: 6739312.
