Amoxapine
Amoxapine is a tricyclic antidepressant that acts as an antagonist at 5-HT2/3/6/7 receptors, D2/3/4 receptors, H1 histamine receptors, α1-adrenergic receptors, and also on the serotonin transporter (SERT) and norepinephrine transporter (NET). Amoxapine also acts as an antagonist at hERG K+ channels, potentially prolonging the cardiac QT interval. Amoxapine exhibits antidepressant, antipsychotic, and antibacterial activities. Amoxapine inhibits GABA- and NMDA-induced increases in intracellular Ca2+ levels and increases leu-enkephalin levels in vivo. This compound exhibits antibiotic activity through inhibition of bacterial β-glucuronidase.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18838256
| Cas No. |
14028-44-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C17H16ClN3O |
| Formula Wt. |
313.78 |
| Chemical Name |
8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine |
| IUPAC Name |
8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine |
| Melting Point |
175.5C |
| Appearance |
Yellow crystalline powder |
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Obers S, Staudacher I, Ficker E, et al. Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):385-400. PMID: 20229012.
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Hamon M, Gozlan H, Bourgoin S, et al. Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology. 1987 Jun;26(6):531-9. PMID: 3037421.
