Product Name :
Genkwanin
Description:
Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.
CAS:
437-64-9
Molecular Weight:
284.26
Formula:
C16H12O5
Chemical Name:
5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one
Smiles :
COC1=CC(O)=C2C(=C1)OC(=CC2=O)C1C=CC(O)=CC=1
InChiKey:
JPMYFOBNRRGFNO-UHFFFAOYSA-N
InChi :
InChI=1S/C16H12O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.DM3 Epigenetic Reader Domain
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Vudalimab medchemexpress
Additional information:
Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.|Product information|CAS Number: 437-64-9|Molecular Weight: 284.PMID:32838699 26|Formula: C16H12O5|Chemical Name: 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one|Smiles: COC1=CC(O)=C2C(=C1)OC(=CC2=O)C1C=CC(O)=CC=1|InChiKey: JPMYFOBNRRGFNO-UHFFFAOYSA-N|InChi: InChI=1S/C16H12O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (17.59 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Cell viability analysis shows that Genkwanin does not affect the cell viability up to a concentration of 50 μM. Genkwanin inhibits the LPS-induced production of NO in a concentration-dependent manner. iNOS only expresses in the present of external stimulus. Genkwanin could not significantly affect the activity of iNOS. The effect of Genkwanin on the production of proinflammatory cytokines is examined. Genkwanin suppresses the productions of TNF-a, IL-1b and IL-6 in LPS stimulated RAW264.7 macrophages in a concentration-dependent manner. Genkwanin significantly suppresses the AP-1 signaling pathway but has little effect on the NF-kB signaling pathway. It is indicated that Genkwanin suppresses the phosphorylation of p38 and JNK in a concentration-dependent manner, but little affects ERK1/2 phosphorylation. Originally identified as an immediate early gene, MKP-1 is then found to be a dual specificity phosphatase acting as a negative regulator of ERK1/2, JNK and p38 MAPK activities, with predominant effects on the latter two. Pretreatment with Genkwanin markedly up-regulates the expression of MKP-1 without affecting MKP-1 mRNA.|Products are for research use only. Not for human use.|
