Product Name :
ZM241385
Description:
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM.
CAS:
139180-30-6
Molecular Weight:
337.34
Formula:
C16H15N7O2
Chemical Name:
4-(2-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]aminoethyl)phenol
Smiles :
NC1=NC(NCCC2C=CC(O)=CC=2)=NC2=NC(=NN21)C1=CC=CO1
InChiKey:
PWTBZOIUWZOPFT-UHFFFAOYSA-N
InChi :
InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM.|Product information|CAS Number: 139180-30-6|Molecular Weight: 337.34|Formula: C16H15N7O2|Chemical Name: 4-(2-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]aminoethyl)phenol|Smiles: NC1=NC(NCCC2C=CC(O)=CC=2)=NC2=NC(=NN21)C1=CC=CO1|InChiKey: PWTBZOIUWZOPFT-UHFFFAOYSA-N|InChi: InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30 mg/mL (88.93 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Mifepristone supplier |Shelf Life: ≥12 months if stored properly.Gramicidin Data Sheet |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32697067 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ZM241385 (1 μM; 24-48 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly upregulates A2AR mRNA and protein levels.|In Vivo:|ZM241385 (0.2 μg/mouse, 0.4 μg/mouse; intraperitoneal injection; every day; for 11 weeks; female C57BL/6 WT mice) treatment decreases tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC.|Products are for research use only. Not for human use.|
