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Product Name :
Butyrolactone 3

Description:
Butyrolactone 3 is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)

CAS:
778649-18-6

Molecular Weight:
184.19

Formula:
C9H12O4

Chemical Name:
(2R,3S)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid

Smiles :
CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O

InChiKey:
SRQUTZJZABSZRQ-RQJHMYQMSA-N

InChi :
InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Butyrolactone 3 is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)|Product information|CAS Number: 778649-18-6|Molecular Weight: 184.Moxifloxacin Autophagy 19|Formula: C9H12O4|Chemical Name: (2R,3S)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid|Smiles: CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O|InChiKey: SRQUTZJZABSZRQ-RQJHMYQMSA-N|InChi: InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.NAD+ supplier |Shelf Life: ≥12 months if stored properly.PMID:33350861 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Biel M,et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6Products are for research use only. Not for human use.|

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Author: Ubiquitin Ligase- ubiquitin-ligase