Product Name :
VAS-2870
Sequence:
Purity:
≥98% (HPLC)
Molecular Weight:
360.4
Solubility :
Soluble in DMSO (up to 10mg/ml) or DMF (up to 25mg/ml).
Appearance:
White to off-white solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Description:
NADPH oxidase inhibitor Novel inhibitor of NAD(P)H oxidase (Nox).2454181-83-8 supplier In vascular smooth muscle cells VAS-2870 completely abolished PDGF-mediated NAD(P)H oxidase activation and ROS production (100% at 10µM). It inhibits PDGF-induced chemotaxis but not proliferation of VSMC. In mouse embryonic stem cells VAS-2870 blocked PDGF-BB-induced vasculogenesis. OxLDL-induced ROS formation in human endothelial cells was completely inhibited by VAS-2870 (100% at 5µM).146426-40-6 References VAS-2870 inhibits PMS-induced oxidative burst in HL-60 cells (IC50=2µM).PMID:29083717
CAS :
722456-31-7
Solubility:
Soluble in DMSO (up to 10mg/ml) or DMF (up to 25mg/ml).
Formula:
C18H12N6OS
Additional Information :
| Alternative Name 3-Benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine | Appearance White to off-white solid. | CAS 722456-31-7 | Couple Target NADPH oxidase | Couple Type Inhibitor | Formula C18H12N6OS | Identity Determined by NMR. | MW 360.4 | Purity ≥98% (HPLC) | Solubility Soluble in DMSO (up to 10mg/ml) or DMF (up to 25mg/ml). | Unit of Measure (UM) mg
