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HHS Public AccessVCAM-1/CD106 Protein Synonyms Author manuscriptChild Abuse Negl. Author manuscript; readily available in PMC 2018 October 01.Published in final edited kind as: Youngster Abuse Negl. 2017 October ; 72: 163sirtuininhibitor71. doi:10.1016/j.chiabu.2017.07.005.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptEffects of childhood trauma exposure and cortisol levels on cognitive functioning amongst breast cancer survivorsCharles Kamen, Ph.D., M.P.Ha,, Caroline Scheiber, Ph.Db, Michelle Janelsins, Ph.D., M.P.Ha, Booil Jo, Ph.Db, Hanyang Shen, M.Ab, and Oxana Palesh, Ph.D., M.P.HbaDepartmentof Surgery, University of Rochester Health-related Center, 265 Crittenden Blvd, Box 420658, Rochester, NY 14642, USAbDepartmentof Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CAAbstractCognitive functioning troubles in breast cancer sufferers receiving chemotherapy are typical, but not all girls practical experience these impairments. Exposure to childhood trauma could impair cognitive functioning following chemotherapy, and these impairments may very well be mediated by dysregulation of hypothalamic-pituitary-adrenal (HPA) axis function and cortisol slope. This study evaluated the association involving childhood trauma exposure, cortisol, and cognition in a sample of breast cancer survivors. 56 girls completed measures of trauma exposure (the Traumatic Events Survey), salivary cortisol, and self-reported cognitive functioning (the Functional Assessment of Cancer Therapy sirtuininhibitorCognitive). We examined correlations among childhood trauma exposure and cognitive functioning, then applied linear regression to handle for variables linked with cognition (age, education, time because chemotherapy, depression, anxiety, and insomnia), as well as the MacArthur approach to test whether or not cortisol levels mediated the relationship amongst trauma and cognitive functioning. 57.1 with the sample had knowledgeable at the very least one traumatic event in childhood, with 19.6 of your sample witnessing a significant injury, 17.9 experiencing physical abuse, and 14.three experiencing sexual abuse. Childhood trauma exposure and cognitive functioning have been moderately connected (r=-0.29). This association remained even when controlling for other.
