Ranial hypertension. Outcomes are provided as medians (IQR).Abbreviations CT: computed
Ranial hypertension. Results are given as medians (IQR).Abbreviations CT: computed tomography; GCS: Glasgow Coma Scale; HES: hydroxyethyl starch; HSS: hypertonic saline option; ICH: intracranial hypertension; ICP: intracranial pressure; SAH: subarachnoid haemorrhage; SID: sturdy ion difference; TBI: traumatic brain damage; WFNS: World Federation of Neurological Societies. Competing interests Karim Asehnoune and Yvonnick Blanloeil have obtained honoraria from B Braun Health care for public speaking. Another authors have no conflicts of interest to disclose. Authors’ contributions Each of the authors participated in the review management, data collection and interpretation of data. OL, AR, CL, YB and KA were accountable for that conception and design of the research, interpretation of information andor creating from the report. RC, ER, PJM, RD, AMC and CP were accountable for information collection, data interpretation andor writing the report. CV carried out statistical examination. LF managed the blinding plus the security of your examine answers. All authors had total access to each of the information during the review and participated during the revision with the manuscript. All authors read and accepted the manuscript for publication. Acknowledgements We gratefully acknowledge Delphine Flattres for her crucial assist together with the examine and the nurses and health care staff of the Surgical Intensive Care Units of Nantes University Hospital for technical assistance. This do the job was supported by B-BRAUN Health care. B-BRAUN Health-related offered the solutions but was not involved while in the study design and style, patient recruitment, data assortment and examination, report writing and publication. The University Hospital of Nantes (UHN) sponsored the review. UHN stored the information, ensured the monitoring with the study. The biostatistics unit (ChristelleConclusions The use of balanced options reduces the incidence of hyperchloraemic acidosis in brain-injured individuals. ICP evolution as well as the price of ICH in brain-injured individuals didn’t seem to become distinct amongst groups. The safety and effect of balanced solutions on neurological recovery, too as the possible unwanted effects of balanced remedies, must be investigated in a large, randomisedRoquilly et al. Critical Care 2013, 17:R77 http:ccforumcontent172RPage 12 ofVolteau) of UHN performed the statistical examination. The community pharmacist (Laurent Flet) blinded the remedies. The results were presented (abstract) on the 53th congress of the French Congress of RGS4 Accession Anaesthesia and Critical Care Medicine (SFAR 2011). Authors’ details 1 P e Anesth ie-R Raf Synonyms nimations, Service d’anesth ie r nimation H el-Dieu, CHU Nantes, F-44000 Nantes, France. 2P e Anesth ie-R nimations, Services d’anesth ie r nimation H ital Laennec, CHU Nantes, F-44000 Nantes, France. 3P e Anesth ie-R nimations, Service de r nimation m icale polyvalente, CHU Nantes, F-44000 Nantes, France. 4P e Pharmacie, Service HOTEL-DIEU-Essais cliniques, CHU Nantes, F-44000 Nantes, France. 5Cellule de Biostatistiques-Cellule de promotion la recherche clinique, CHU Nantes, F-44000 Nantes, France. Received: 8 December 2012 Revised: 14 December 2012 Accepted: 19 April 2013 Published: 19 April 2013 References 1. Mathers CD, Loncar D: Projections of global mortality and burden of illness from 2002 to 2030. PLoS Med 2006, three:e442. 2. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA: The role of secondary brain damage in identifying outcome from extreme head damage. J Trauma 1993, 34:216.
