Experiments; SvK, MAEH, AC, AM, FA and KP contributed experimentally. MAE-B.
Experiments; SvK, MAEH, AC, AM, FA and KP contributed experimentally. MAE-B. performed histopathological examinations of tumor tissues in a blinded manner.1. Pommier Y, Sordet O, Antony S, Hayward RL, Kohn KW. Caspase 6 Purity & Documentation apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 2004; 23: 2934949. two. Creagan ET, Kovach JS, Moertel CG, Frytak S, Kvols LK. A phase I clinical trial of recombinant human tumor necrosis element. Cancer 1988; 62: 2467471. three. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y et al. Lethal effect on the anti-Fas antibody in mice. Nature 1993; 364: 80609.Cell Death and DifferentiationCDK9 inhibition overcomes TRAIL resistance J Lemke et al4. Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA et al. Security and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999; 104: 15562. five. Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999; 5: 15763. six. Micheau O, Shirley S, Dufour F. Death receptors as targets in cancer. Br J Pharmacol 2013; 169: 1723744. 7. Todaro M, Lombardo Y, Francipane MG, Alea MP, Cammareri P, Iovino F et al. Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4. Cell Death Differ 2008; 15: 76272. 8. Pan G, O’Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J et al. The receptor for the cytotoxic ligand TRAIL. Science 1997; 276: 11113. 9. Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N et al. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J 1997; 16: 5386397. 10. Kischkel FC, Lawrence DA, Chuntharapai A, Schow P, Kim KJ, Ashkenazi A. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors four and 5. Immunity 2000; 12: 61120. 11. Kischkel FC, Lawrence DA, Tinel A, KDM3 list LeBlanc H, Virmani A, Schow P et al. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation inside the absence of caspase-8. J Biol Chem 2001; 276: 466396646. 12. Sprick MR, Rieser E, Stahl H, Grosse-Wilde A, Weigand MA, Walczak H. Caspase-10 is recruited to and activated in the native TRAIL and CD95 death-inducing signalling complexes inside a FADD-dependent manner but can not functionally substitute caspase-8. EMBO J 2002; 21: 4520530. 13. Sprick MR, Weigand MA, Rieser E, Rauch CT, Juo P, Blenis J et al. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are vital for apoptosis mediated by TRAIL receptor two. Immunity 2000; 12: 59909. 14. Dickens LS, Boyd RS, Jukes-Jones R, Hughes MA, Robinson GL, Fairall L et al. A death effector domain chain DISC model reveals a critical role for caspase-8 chain assembly in mediating apoptotic cell death. Mol Cell 2012; 47: 29105. 15. Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC et al. XIAP discriminates involving sort I and form II FAS-induced apoptosis. Nature 2009; 460: 1035039. 16. Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S. Cellular FLICE-inhibitory protein splice variants inhibit various steps of caspase-8 activation at the CD95 deathinducing signaling complex. J Biol Chem 2001; 276: 206330640. 17. Salvesen GS, Duckett CS. IAP proteins: blocking the road to death’s door. Nat Rev Mol Cell Biol 2002; three: 40110. 18. Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is usually a direct inhibitor of celldeath proteases. Nature 1997; 388.
