Linesterase inhibitory and antioxidant properties of Cyclotrichium niveum, Thymus praecox subsp. caucasicus var. caucasicus, Echinacea purpurea and E. pallid. Food Chem Toxicol 2009, 47:1304?310.doi:10.1186/1472-6882-12-117 Cite this article as: Orsoli et al.: Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice. BMC Complementary and Alternative Medicine 2012 12:117.
Konat?et al. BMC Complementary and Alternative Medicine 2012, 12:120 http://www.biomedcentral.com/1472-6882/12/RESEARCH ARTICLEOpen AccessToxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f. and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina FasoKiessoun Konat?,4*, Ima Henri Nestor Bassol?, Adama Hilou1, Ra sa RR Aworet-Samseny3, Alain Souza4, Nicolas Barro5, Mamoudou H Dicko2, Jacques Y Datt? and Bertrand M’BatchiAbstractBackground: Sida acuta Burn f. and Sida cordifolia L. (Malvaceae) are traditionally used in Burkina Faso to treat several ailments, mainly pains, including abdominal infections and associated diseases. Despite the extensive use of these plants in traditional health care, literature provides little information regarding their toxicity and the pharmacology. This work was therefore designed to investigate the toxicological effects of aqueous acetone extracts of Sida acuta Burn f. and Sida cordifolia L. Furthermore, their analgesic capacity was assessed, in order to assess the efficiency of the traditional use of these two medicinal plants from Burkina Faso. Method: For acute toxicity test, mice were injected different doses of each extract by intraperitoneal route and the LD50 values were determined. For the subchronic toxicity evaluation, Wistar albinos rats were treated by gavage during 28 days at different doses of aqueous acetone extracts and then haematological and biochemical parameters were determined. The analgesic Biotin-VAD-FMK site 25679764″ title=View Abstract(s)”>PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25679764 effect was evaluated in mice by the acetic-acid writhing test and by the formalin test. Results: For the acute toxicity test, the LD50 values of 3.2 g/kg and 3.4 g/kg respectively for S. acuta Burn f. and S. cordifolia L. were obtained. Concerning the haematological and biochemical parameters, data varied widely (increase or decrease) according to dose of extracts and weight of rats and did not show clinical correlations. The extracts have produced significant analgesic effects by the acetic acid writhing test and by the hot plate method (p <0.05) and a dose-dependent inhibition was observed. Conclusion: The overall results of this study may justify the traditional uses of S. acuta and S. cordifolia.Background Indigenous medicinal plants were and are still one of the sources of modern medicines [1]. Moreover the trend of using phytotherapy as alternative medicine has increased the interest for the tropical plants' pharmacognosy [2]. In Africa, especially in Burkina Faso, medicinal plants still play an important role in health care of an important* Correspondence: [email protected] 1 Laboratory of Biochemistry and Applied Chemistry, University of Ouagadougou, 09 P.O.Box: 848, Ouagadougou 09, Burkina Faso 4 Laboratory of Animal Physiology, Electrophysiology and Pharmacology, Faculty of Sciences, University of Science and Technology of Masuku, Franceville, Gabon Full list of author information is available at the end of the articleportion of the population. This is because they are cheap, are locally available and efficient. Generally, the effects.
