Share this post on:

Utation in a failing raltegravir containing regimen. AIDS. 2008;22:2045?. Trevino A, de
Utation in a failing raltegravir containing regimen. AIDS. 2008;22:2045?. Trevino A, de Mendoza C, Caballero E, Rodriguez C, Parra P, Benito R, et al. Drug resistance mutations in patients infected with HIV-2 living in Spain. J Antimicrob Chemother. 2011;66:1484?. Salgado M, Toro C, Simon A, Garrido C, Blanco F, Soriano V, et al. Mutation N155H in HIV-2 integrase confers high PD173074 clinical trials phenotypic resistance to raltegravir and impairs replication capacity. J Clin Virol. 2009;46:173?. Trevino A, Parra P, Cabezas T, Lozano AB, Garcia-Delgado R, Force L, et al. Drug resistance mutations in HIV-2 patients failing raltegravir – extent of cross-resistance to dolutegravir. Antivir Ther. 2013;18 Suppl 1:A105. Ni XJ, Delelis O, Charpentier C, Storto A, Collin G, Damond F, et al. G140S/ Q148R and N155H mutations render HIV-2 Integrase resistant to raltegravir whereas Y143C does not. Retrovirology. 2011;8:68. Grobler JA, Hazuda DJ. Resistance to HIV integrase strand transfer inhibitors: in vitro findings and clinical consequences. Curr Opin Virol. 2014;8C:98?03. Hurt CB, Sebastian J, Hicks CB, Eron JJ. Resistance to HIV integrase strand transfer inhibitors among clinical specimens in the United States, 2009-2012. Clin Infect Dis. 2014;58:423?1. Abram ME, Hluhanich RM, Goodman DD, Andreatta KN, Margot NA, Ye L, et al. Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness. Antimicrob Agents Chemother. 2013;57:2654?3. Menendez-Arias L. Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments. Antiviral Res. 2013;98:93?20. Huang W, Frantzell A, Fransen S, Petropoulos CJ. Multiple genetic PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25609842 pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir. Antimicrob Agents Chemother. 2013;57:4105?3. Geretti AM, Armenia D, Ceccherini-Silberstein F. Emerging patterns and implications of HIV-1 integrase inhibitor resistance. Curr Opin Infect Dis. 2012;25:677?6. Wainberg MA, Mesplede T, Quashie PK. The development of novel HIV integrase inhibitors and the problem of drug resistance. Curr Opin Virol. 2012;2:656?2.43. Winters MA, Lloyd Jr RM, Shafer RW, Kozal MJ, Miller MD, Holodniy M. Development of elvitegravir resistance and linkage of integrase inhibitor mutations with protease and reverse transcriptase resistance mutations. PLoS One. 2012;7:e40514. 44. Mesplede T, Quashie PK, Wainberg MA. Resistance to HIV integrase inhibitors. Curr Opin HIV AIDS. 2012;7:401?. 45. Garrido C, Villacian J, Zahonero N, Pattery T, Garcia F, Gutierrez F, et al. Broad phenotypic cross-resistance to elvitegravir in HIV-infected patients failing on raltegravir-containing regimens. Antimicrob Agents Chemother. 2012;56:2873?. 46. Blanco JL, Varghese V, Rhee SY, Gatell JM, Shafer RW. HIV-1 integrase inhibitor resistance and its clinical implications. J Infect Dis. 2011;203:1204?4. 47. Kobayashi M, Yoshinaga T, Seki T, Wakasa-Morimoto C, Brown KW, Ferris R, et al. In vitro antiretroviral properties PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/29072704 of S/GSK1349572, a next-generation HIV integrase inhibitor. Antimicrob Agents Chemother. 2011;55:813?1. 48. da Silva D, Van Wesenbeeck L, Breilh D, Reigadas S, Anies G, Van Baelen K, et al. HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containin.

Share this post on:

Author: Ubiquitin Ligase- ubiquitin-ligase