Up 2-B, the number of mature eggs was higher (P = 0.019), theTable
Up 2-B, the number of mature eggs was higher (P = 0.019), theTable 2 Hormonal profile and ultrasound measurements in treatment groupsGroup 1-A r FSH + Low dose hCG < 40 y N = 49 CD3 FSH (IU/L) CD3 LH (IU/L) CD3 E2 (pmol/L) CD 3 Progesterone (nmol/L) FSH (IU/ML) on day of HCG admin Estradiol (pmol/L) on day of HCG admin Estradiol (pmol/L) at HCG admin/Mature egg Progesterone (nmol/L) on day of HCG admin Endometrial thickness (mm) on day of HCG admin 5.38 ?2.61 3.55 ?2.61 112.23 ?131.99 4.13 ?2.42 13.35 ?5.14 8354.51 ?4171.09 1296.84 ?1154.87 8.54 ?4.23 1.02 ?0.27 Group 2-A r FSH < 40 y N = 67 5.78 ?3.26 3.67 ?0.58 114.73 ?51.89 3.33 ?2.23 14.38 ?6.35 8226.81 ?5262.10 935.25 ?436.13 6.87 ?3.49 1.04 ?0.25 P Value Group 1-B r FSH + Low dose hCG 40 y N = 39 6.97 ?2.1 3.63 ?2.02 120.39 ?105.46 4.21 ?2.07 17.38 ?4.93 8692.51 ?174.06 1933.70 ?1475.24 7.59 ?3.88 0.98 ?0.25 Group 2-B r FSH 40 y N = 32 7.42 ?2.78 4.37 ?2.85 123.84 ?37.04 5.57 ?4.48 19.96 ?5.83 6858.54 ?3461.78 2214.41 ?1946.52 6.48 ?2.38 0.921 ?.026 P Value0.243 0.19 0.451 0.063 0.486 0.443 0.025 0.016 0.0.232 0.119 0.426 0.066 0.037 0.027 0.265 0.081 0.Both groups were comparable with regard to their baseline hormonal profile.Gomaa et al. Reproductive Biology and Endocrinology 2012, 10:55 http://www.rbej.com/content/10/1/Page 4 ofTable 3 Cycle outcome measuresGroup 1-A r FSH + Low dose hCG < 40 y N = 49 PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28854080 Starting dose of FSH Total dose of FSH. Treatment duration, days Need for dose change No of retrieved oocytes No of mature eggs No of fertilized eggs Fertilization rate per retrieved oocyte No of Embryos per transfer No of frozen embryos Total pregnancies per cycle started Total pregnancies per cycle completed Cancelled cycles Hyper stimulation No eggs retrieved 246.43 ?61.45 2,496 ?774 10.02 ?1.73 8/94 (8.5 ) 10.83 ?6.55 9.49 ?5.78 6.71 ?4.43 61.47 ?18.38 2.66 ?1.22 2.90 ?3.66 12/49 (24.49 ) 12/45 (26.67 ) 3 0 1 Group 2-A r FSH < 40 y N = 67 238.06 ?71.96 2,284 ?843 9.45 ?1.48 12/67 (17.9 ) 12.50 ?7.29 10.37 ?6.55 7.35 ?4.35 62.97 ?21.39 2.68 ?1.16 4.14 ?4.62 23/67 (34.33 ) 23/60 (38.33 ) 2 5 0 P Value Group 1-B r FSH + Low dose hCG 40 y N = 39 302.56 ?41.28 3,217 ?874 10.03 ?1.58 5/39 (12.8 ) 7.92 ?4.32 5.72 ?3.52 4.89 ?2.74 58.96 ?19.48 2.92 ?1.09 1.03 ?2.13 6/39 (15.38 ) 6/38 (15.79 ) 0 0 1 Group 2-B r FSH 40 y N = 32 322.65 ?60.03 3,264 ?1,009 9.40 ?1.90 4/32 (12.5 ) 6.28 ?4.50 4.00 ?3.34 3.70 ?2.09 58.72 ?33.48 3.00 ?1.37 0.296 ?0.95 3/32 (9.38 ) 3/27 (11.11 ) 4 0 1 P Value0.501 0.082 0.064 0.412 0.10 0.230 0.227 0.347 0.459 0.128 0.416 0.0.114 0.415 0.072 0.193 0.067 0.019 0.027 0.394 0.399 0.033 0.090 0.number of fertilized eggs was higher (P = 0.027) and the number of frozen embryos (0.033) was higher in group 1-B. (Table 3) Overall, there were no differences in endometrial thickness or fertilization rates in any of the groups. Pregnancy rates were not significantly different between group 1-A and 2-A, and between 1-B and 2-B.Cost analysisThe cost was determined using the average cost of a single unit of recFSH which was approximately PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27465830 Canadian 1.00 during this study. The cost-effectiveness ratio was calculated by determining the average cost of the stimulation AZD-8835 site protocol for each mature oocyte. The overall cost of medications per cycle started was almost the same but the cost/mature follicle was less in the low dose hCG group in the women > 40 years of age (P = 0.053). The average cost/mature follicle in group (1-B) was 878.78 while in the FSH only group (2-B) it.
