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n-Octyl-3-methylcaffeate

This product is a hydroxycinnamic acid and derivative of n-ocytl caffeate. n-Octyl caffeate exhibits antioxidative, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. n-Octyl caffeate decreases lipid peroxidation, activity of xanthine oxidase, activation of JNK and ERK, and production of NO and iNOS in rat brain homogenate; it also prevents the LPS-induced drop in mean arterial pressure in aortic smooth muscle cells. In animal models of tumor metastasis, n-octyl caffeate decreases tumor nodules.

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18947034

Purity

≥98%

Formula

C18H26O4

Formula Wt.

306.40

Synonym

3-Methylcaffeic acid n-octyl ester; 4-Hydroxy-3-methoxycinnamic acid n-octyl ester

Appearance

White Crystal

Nagaoka T, Banskota AH, Tezuka Y, et al. Inhibitory effects of caffeic acid phenethyl ester analogues on experimental lung metastasis of murine colon 26-L5 carcinoma cells. Biol Pharm Bull. 2003 May;26(5):638-41. PMID: 12736504.

Hsiao G, Shen MY, Chang WC, et al. A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells. Biochem Pharmacol. 2003 Apr 15;65(8):1383-92. PMID: 12694879.

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